Zein-based oral drug delivery system targeting activated macrophages

Sungmun Lee, Noaf Salah Ali Alwahab, Zainab Muhammad Moazzam

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Reactive oxygen species (ROS) play an important role in the pathogenesis of rheumatoid arthritis (RA). ROS such as hydrogen peroxide and superoxide are overproduced by activated macrophages in RA. As scavengers of ROS, enzymatic proteins such as catalase and superoxide dismutase (SOD) have a great therapeutic potential; however, in vivo application is limited especially when they are orally administered. Although, the oral route is the most convenient for drug administration, therapeutic proteins are easily degraded in vivo by the harsh conditions of gastrointestinal (GI) tract. Here, we introduce a novel drug delivery system composed of zein, a plant storage protein derived from maize. We demonstrate that zein nanoparticles can protect therapeutic proteins, catalase and SOD, from the harsh conditions of GI tract. Folate-conjugated catalase or SOD in zein nanoparticles can target the activated macrophages and scavenge the ROS generated by macrophages in vitro. This novel drug delivery system will be applicable to other orally administered treatments based on the protective property in the harsh conditions of GI tract.

Original languageBritish English
Pages (from-to)388-393
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume454
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Inflammatory disease
  • Oral drug delivery
  • Reactive oxygen species
  • Zein

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