@article{694f8dc78f904ae3994589510680f41a,
title = "Y-Chromosome haplotypes reveal relationships between populations of the Arabian Peninsula, North Africa and South Asia",
abstract = "Background: The United Arab Emirates (UAE) is positioned at the crossroads of human migration out of Africa and through to Asia and Europe. Aim: To compare the degree of genetic diversity of the Arabian UAE population with populations in other countries from the Middle East, South Asia and North Africa. Subjects and methods: Twenty-seven Y-STR were analysed in 217 individuals. Y-STR haplotypes from this study were compared to population data stored in YHRD, using MDS and AMOVA. Results: Two hundred and twelve haplotypes were observed in the 217 individuals studied. Although the reduction in Y-STR loci from 27 to 17 resulted in a decrease in discriminatory power, comparisons of populations were possible. The UAE population clustered closer with other populations of the Middle East. The South Asian and North African populations were separated by Middle Eastern populations in between both clusters. Conclusion: This is the first study to report the diversity of a population of the Arabian Peninsula using 27 Y-STR. MDS plots show that Middle Eastern populations are positioned in the centre, with African, Asian and European populations around the Arab population cluster. The findings of this study are consistent with this region being at the epicentre of human migration between continents.",
keywords = "population genetics, United Arab Emirates, Y-chromosome STRs, Y-Filer PLUS amplification kit",
author = "Jones, {Rebecca J.} and Tay, {Guan K.} and Aur{\'e}lie Mawart and Habiba Alsafar",
note = "Funding Information: The DNA samples of 217 healthy, unrelated males from the UAE who consented to participate in the study were used. These samples were available as de-identified DNA samples stored for research purposes in the Emirates Family Registry (EFR), a biobank resource available for genetic association studies (Alsafar et al., 2012). Prior to commencement of this present study, approval to undertake the work was obtained from the Human Research Ethics Committee of the University of Western Australia (RA/4/1/7778) and the IRB of the Ministry of Health of the UAE. Funding Information: aSchool of Anatomy, Physiology and Human Biology, University of Western Australia, Crawley, WA, Australia; bSchool of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia; cSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; dCenter for Biotechnology, Khalifa University of Science, Technology and Research, Abu Dhabi, United Arab Emirates; eFaculty of Biomedical Engineering, Khalifa University of Science, Technology and Research, Abu Dhabi, United Arab Emirates Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2017",
month = nov,
day = "17",
doi = "10.1080/03014460.2017.1384508",
language = "British English",
volume = "44",
pages = "738--746",
journal = "Annals of Human Biology",
issn = "0301-4460",
publisher = "Informa Healthcare",
number = "8",
}