Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

Abd Elgawad Radi; Shimaa Eissa

doi:10.1007/s10847-010-9801-9

Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

Abd Elgawad Radi, Shimaa Eissa

Chemistry

Faculty of Science

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M^-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as A_L-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, K_S, of 846 M^-1.

Original language	British English
Pages (from-to)	417-421
Number of pages	5
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume	68
Issue number	3-4
DOIs	https://doi.org/10.1007/s10847-010-9801-9
State	Published - Dec 2010

Keywords

Cyclodextrin
Glibenclamide
Spectrophotometry
Voltammetry

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10.1007/s10847-010-9801-9

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title = "Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin",

abstract = "The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, KS, of 846 M-1.",

keywords = "Cyclodextrin, Glibenclamide, Spectrophotometry, Voltammetry",

author = "Radi, {Abd Elgawad} and Shimaa Eissa",

year = "2010",

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doi = "10.1007/s10847-010-9801-9",

language = "British English",

volume = "68",

pages = "417--421",

journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",

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T1 - Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

AU - Radi, Abd Elgawad

AU - Eissa, Shimaa

PY - 2010/12

Y1 - 2010/12

N2 - The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, KS, of 846 M-1.

AB - The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M-1, respectively. The phase solubility profile, based on the spectrophotometric absorbance's variations, was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, KS, of 846 M-1.

KW - Cyclodextrin

KW - Glibenclamide

KW - Spectrophotometry

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=78649316150&partnerID=8YFLogxK

U2 - 10.1007/s10847-010-9801-9

DO - 10.1007/s10847-010-9801-9

M3 - Article

AN - SCOPUS:78649316150

SN - 0923-0750

VL - 68

SP - 417

EP - 421

JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry

JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry

IS - 3-4

ER -

Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

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Keywords

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