Abstract
The formation of an inclusion complex of hypoglycaemic drug, glipizide with β-cyclodextrin has been investigated by cyclic, differential pulse voltammetry and UV-vis spectrophotometry. The formation constants of the complex were determined using differential pulse voltammetry and UV-vis spectrophotometry, respectively. For comparative purpose, we have also applied phase solubility study with spectrophotometric detection obtaining formation constant value of 620 M -1. The phase solubility profile was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glipizide with β-cyclodextrin.
| Original language | British English |
|---|---|
| Pages (from-to) | 13-21 |
| Number of pages | 9 |
| Journal | Eurasian Journal of Analytical Chemistry |
| Volume | 6 |
| Issue number | 1 |
| State | Published - 2011 |
Keywords
- Cyclodextrin
- Glipizide
- Spectrophotometry
- Voltammetry