@inproceedings{a088d067a134400199c95c328b441c90,
title = "Viscoelastic properties of human mesenchymal stem cells",
abstract = "In this study, we investigated the viscoelasticity of individual bone marrow-derived adult human Mesenchymal Stem Cells (hMSCs), and the role of specific cytoskeletal component-F-actin microfilaments on the mechanical properties of individual hMSCs. The mechanical properties of hMSCs were determined using the micropipette aspiration technique coupled with a viscoelastic solid model of the cell. For the hMSCs under control conditions the instantaneous Young's modulus E0 was found to be 886±289(Pa), the equilibrium Young's modulus E∞ 372±125(Pa), and the apparent viscosity μ, 2714±1626(Pa·S). After exposed to 2μM of chemical agent-cytochalasin D that disrupt the F-actin microfilaments, the Young's moduli of hMSCs decreased by up to 72\% and the apparent viscosity increased by 167\%. These findings suggest that microfilaments are crucial in providing the viscoelastic properties of the hMSCs, and changes in the structure and properties of them may influence the mechanical properties of hMSCs significantly.",
keywords = "Actin, Apparent viscosity, Equilibrium young's modulus, Human Mesenchymal Stem Cells (hMSCs), Instantaneous young's modulus, Mechanical properties, Micropipette aspiration, Viscoelasticity",
author = "Wenxiao Pan and Erik Petersen and Ning Cai and Gang Ma and Lee, \{Jian Run\} and Zhiqin Feng and Kin Liao and Leong, \{Kam W.\}",
year = "2005",
language = "British English",
isbn = "0780387406",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
pages = "4854--4857",
booktitle = "Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005",
note = "2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 ; Conference date: 01-09-2005 Through 04-09-2005",
}