Update from the Laboratory: Clinical Identification and Susceptibility Testing of Fungi and Trends in Antifungal Resistance

Mohammad T. Albataineh; Deanna A. Sutton; Annette W. Fothergill; Nathan P. Wiederhold

doi:10.1016/j.idc.2015.10.014

Update from the Laboratory: Clinical Identification and Susceptibility Testing of Fungi and Trends in Antifungal Resistance

Mohammad T. Albataineh, Deanna A. Sutton, Annette W. Fothergill, Nathan P. Wiederhold

College of Medicine and Health Sciences

University of Texas Health Science Center at San Antonio

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Despite the availability of new diagnostic assays and broad-spectrum antifungal agents, invasive fungal infections remain a significant challenge to clinicians and are associated with marked morbidity and mortality. In addition, the number of etiologic agents of invasive mycoses has increased accompanied by an expansion in the immunocompromised patient populations, and the use of molecular tools for fungal identification and characterization has resulted in the discovery of several cryptic species. This article reviews various methods used to identify fungi and perform antifungal susceptibility testing in the clinical laboratory. Recent developments in antifungal resistance are also discussed.

Original language	British English
Pages (from-to)	13-35
Number of pages	23
Journal	Infectious Disease Clinics of North America
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.idc.2015.10.014
State	Published - 1 Mar 2016

Keywords

Antifungal resistance
Antifungal susceptibility testing
Fungal identification

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10.1016/j.idc.2015.10.014

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title = "Update from the Laboratory: Clinical Identification and Susceptibility Testing of Fungi and Trends in Antifungal Resistance",

abstract = "Despite the availability of new diagnostic assays and broad-spectrum antifungal agents, invasive fungal infections remain a significant challenge to clinicians and are associated with marked morbidity and mortality. In addition, the number of etiologic agents of invasive mycoses has increased accompanied by an expansion in the immunocompromised patient populations, and the use of molecular tools for fungal identification and characterization has resulted in the discovery of several cryptic species. This article reviews various methods used to identify fungi and perform antifungal susceptibility testing in the clinical laboratory. Recent developments in antifungal resistance are also discussed.",

keywords = "Antifungal resistance, Antifungal susceptibility testing, Fungal identification",

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AU - Albataineh, Mohammad T.

AU - Sutton, Deanna A.

AU - Fothergill, Annette W.

AU - Wiederhold, Nathan P.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Despite the availability of new diagnostic assays and broad-spectrum antifungal agents, invasive fungal infections remain a significant challenge to clinicians and are associated with marked morbidity and mortality. In addition, the number of etiologic agents of invasive mycoses has increased accompanied by an expansion in the immunocompromised patient populations, and the use of molecular tools for fungal identification and characterization has resulted in the discovery of several cryptic species. This article reviews various methods used to identify fungi and perform antifungal susceptibility testing in the clinical laboratory. Recent developments in antifungal resistance are also discussed.

AB - Despite the availability of new diagnostic assays and broad-spectrum antifungal agents, invasive fungal infections remain a significant challenge to clinicians and are associated with marked morbidity and mortality. In addition, the number of etiologic agents of invasive mycoses has increased accompanied by an expansion in the immunocompromised patient populations, and the use of molecular tools for fungal identification and characterization has resulted in the discovery of several cryptic species. This article reviews various methods used to identify fungi and perform antifungal susceptibility testing in the clinical laboratory. Recent developments in antifungal resistance are also discussed.

KW - Antifungal resistance

KW - Antifungal susceptibility testing

KW - Fungal identification

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JO - Infectious Disease Clinics of North America

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IS - 1

ER -

Update from the Laboratory: Clinical Identification and Susceptibility Testing of Fungi and Trends in Antifungal Resistance

Abstract

Keywords

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