Ultrasound-assisted liquid biphasic system

Shir Reen Chia, Albert Fu Xian Lim, Kit Wayne Chew, Pau Loke Show

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


An integrated method of cell disruption with primary separation is discussed in this chapter. Ultrasound-assisted liquid biphasic systems (UA-LBSs) are an integrated method with adjustable parameters, including the phase forming components, conditions of ultrasound, processing time and more. The basic working principle of UA-LBSs are highlighted with their major applications. UA-LBSs are mostly used in pretreating and extracting materials or components, as they integrate gentle cell disruption method with effective separation technique for short processing time, lower volume of solvent required, and reduced cost for overall process. The efficiency of the system is susceptible to changes in the operating parameters and targeted compounds. The advantages and limitations of this technique, as well as the potential for scaling up the system, are also discussed in this chapter. It is seen to be a promising technology for both laboratory- and industrial-scale applications.

Original languageBritish English
Title of host publicationLiquid Biphasic System
Subtitle of host publicationFundamentals and Applications in Bioseparation Technology
Number of pages18
ISBN (Electronic)9780128199862
StatePublished - 1 Jan 2020


  • Cell disruption
  • Extraction
  • Liquid Biphasic System
  • Purification
  • Ultrasound-assisted


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