Treatment of vaginal agglutination associated with chronic graft-versus-host disease

Objective: To describe the presentation and clinical course of two patients after development of vaginal agglutination associated with chronic graft-versus-host disease. Design: Case report. Setting: Tertiary referral center for pelvic reconstructive surgery. Patient(s): Two patients with the diagnosis of chronic graft-versus-host disease who later developed vaginal agglutination requiring treatment. Intervention(s): Surgical lysis of vaginal adhesions and postoperative use of vaginal dilators. Main Outcome Measure(s): Successful treatment of vaginal adhesions. Result(s): Both patients underwent successful surgical lysis of vaginal adhesions and maintained vaginal patency with postoperative use of vaginal dilators. Conclusion(s): Prompt diagnosis of vaginal agglutination in patients with chronic graft-versus-host disease and appropriate surgical correction of this complication rather than prophylaxis is the correct treatment course.