Abstract
Metabolic biomarkers are very popular in clinical laboratories, where more than 95% of the clinical assays are based on small molecules. Biosensors can offer a faster, simpler, and cheaper alternative to conventional analytical assays as they can make the metabolic biomarkers more accessible in a high-throughput fashion for point-of-care testing. As research continues in different aspects of the biosensor design, more sensitive and selective biosensors are being developed for various metabolic biomarkers for diagnostic applications. In this chapter, we provide a brief overview of the current biosensor designs and formats for applications in metabolomics. Various biorecognition receptors and transducers used in the development of biosensors for metabolic biomarkers are discussed. Major advances in the biosensors for metabolites such as the use of aptamers as new recognition receptors as well as the utilization of nanomaterials as transducers are highlighted. The developments of multiplexed array biosensors for the simultaneous detection of multiple biomarkers and wearable biosensors are discussed as emerging diagnostic tools in metabolomics. The challenges and future perspectives in the use of biosensors in metabolomics are discussed.
| Original language | British English |
|---|---|
| Title of host publication | The Advanced Technology and Clinical Application in Metabolomics |
| Publisher | Springer Nature |
| Pages | 397-350 |
| Number of pages | 48 |
| ISBN (Electronic) | 9789819951628 |
| ISBN (Print) | 9789819951611 |
| DOIs | |
| State | Published - 1 Jan 2023 |
Keywords
- Biosensing platforms Metabolic biomarkers Point-of-care biosensors Metabolomics Electrochemical biosensors Optical biosensors Multiplexed array biosensors Detection