TY - JOUR
T1 - Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum
AU - Balu, Sridharan
AU - Palanisamy, Selvakumar
AU - Velusamy, Vijaylakshmi
AU - Yang, Thomas C.K.
AU - El-Shafey, El Said I.
N1 - Funding Information:
This project was supported by the Ministry of Science and Technology (project No: 106-2119- M -027-001 ) of Taiwan. This work was jointly sponsored by the Engineering and Materials Research Centre (EMRC) , School of Engineering, Manchester Metropolitan University , Manchester, UK. Authors also would like to acknowledge the Precision analysis and Materials Research Center, National Taipei University of Technology for providing the all-necessary Instrument facilities.
Funding Information:
This project was supported by the Ministry of Science and Technology (project No: 106-2119-M-027-001) of Taiwan. This work was jointly sponsored by the Engineering and Materials Research Centre (EMRC), School of Engineering, Manchester Metropolitan University, Manchester, UK. Authors also would like to acknowledge the Precision analysis and Materials Research Center, National Taipei University of Technology for providing the all-necessary Instrument facilities.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/3
Y1 - 2020/3
N2 - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.
AB - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.
KW - Biosensor
KW - Dopamine
KW - Graphene nanocomposite
KW - Guest-host chemistry
KW - SnS nanorods
KW - Sonochemical method
UR - http://www.scopus.com/inward/record.url?scp=85074996006&partnerID=8YFLogxK
U2 - 10.1016/j.msec.2019.110367
DO - 10.1016/j.msec.2019.110367
M3 - Article
C2 - 31923993
AN - SCOPUS:85074996006
SN - 0928-4931
VL - 108
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110367
ER -