Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat

B. Tjaden; D. Galetto; J. D. Woodruff; J. A. Rock

doi:10.1016/S0015-0282(16)55705-7

Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat

B. Tjaden, D. Galetto, J. D. Woodruff, J. A. Rock

College of Medicine and Health Sciences

Emory University School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objective: To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat. Design: Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment. Participants: Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g. Setting: Departmental research laboratory of university hospital. Intervention: Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks. Main Outcome Measures: Size of the implant was measured before and after treatment; relative change in size of the implants was calculated. Results: There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups. Conclusions: RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.

Original language	British English
Pages (from-to)	437-440
Number of pages	4
Journal	Fertility and Sterility
Volume	59
Issue number	2
DOIs	https://doi.org/10.1016/S0015-0282(16)55705-7
State	Published - 1993

Keywords

Endometriosis
RU486 (mefiprostone)

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10.1016/S0015-0282(16)55705-7

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title = "Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat",

abstract = "Objective: To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat. Design: Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment. Participants: Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g. Setting: Departmental research laboratory of university hospital. Intervention: Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks. Main Outcome Measures: Size of the implant was measured before and after treatment; relative change in size of the implants was calculated. Results: There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups. Conclusions: RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.",

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T1 - Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat

AU - Tjaden, B.

AU - Galetto, D.

AU - Woodruff, J. D.

AU - Rock, J. A.

PY - 1993

Y1 - 1993

N2 - Objective: To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat. Design: Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment. Participants: Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g. Setting: Departmental research laboratory of university hospital. Intervention: Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks. Main Outcome Measures: Size of the implant was measured before and after treatment; relative change in size of the implants was calculated. Results: There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups. Conclusions: RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.

AB - Objective: To evaluate the time-dependent effect of the progesterone antagonist RU486 on experimentally induced endometriosis in the rat. Design: Endometriosis was induced by implanting endometrium onto the peritoneal side wall. Size of the implants was measured before and after treatment. Participants: Fifty-two adult female Sprague-Dawley female rats weighing 200 to 225 g. Setting: Departmental research laboratory of university hospital. Intervention: Animals treated with RU486 or vehicle only for 2, 4, 6, or 8 weeks. Main Outcome Measures: Size of the implant was measured before and after treatment; relative change in size of the implants was calculated. Results: There was not a statistically significant difference between the treatment groups and the control groups. There was no regression of endometriosis in any of the treatment groups. Conclusions: RU486 administered for 8 weeks in the rat model was not effective therapy for endometriosis.

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Time-related effects of RU486 treatment in experimentally induced endometriosis in the rat

Abstract

Keywords

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