Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

V. L. Zanagnolo; R. Beck; W. D. Schlaff; M. D. Damewood; D. Bobbie; J. A. Rock

doi:10.1016/s0015-0282(16)54137-5

Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

V. L. Zanagnolo, R. Beck, W. D. Schlaff, M. D. Damewood, D. Bobbie, J. A. Rock

College of Medicine and Health Sciences

The Johns Hopkins Hospital

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6, and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for ≥4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.

Original language	British English
Pages (from-to)	411-415
Number of pages	5
Journal	Fertility and Sterility
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/s0015-0282(16)54137-5
State	Published - 1991

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title = "Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat",

abstract = "The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6, and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for ≥4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.",

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T1 - Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

AU - Zanagnolo, V. L.

AU - Beck, R.

AU - Schlaff, W. D.

AU - Damewood, M. D.

AU - Bobbie, D.

AU - Rock, J. A.

PY - 1991

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N2 - The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6, and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for ≥4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.

AB - The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6, and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for ≥4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.

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Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

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