Three-component diastereoselective cascade synthesis of thiohydantoins

Victor Ceban, Kane Hands, Marta Meazza, Mark E. Light, Ramon Rios

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A new three-component cascade reaction for the synthesis of thiohydantoins is reported. The reaction between α-amino esters, nitrostyrenes, and aromatic isothiocyanates is efficiently promoted by organic bases to afford highly substituted thiohydantoins in moderate to good yields and diastereoselectivities.

Original languageBritish English
Pages (from-to)7183-7187
Number of pages5
JournalTetrahedron Letters
Volume54
Issue number52
DOIs
StatePublished - 25 Dec 2013

Keywords

  • Cascade reactions
  • Diastereoselective
  • Edman degradation
  • Organocatalysis
  • Thiohydantoins

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