Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin

Oualid Alioui; Widad Sobhi; Matteo Tiecco; Inas M. Alnashef; Ayoub Attoui; Amel Boudechicha; Krishna Kumar Yadav; Ahmed M. Fallatah; Noureddine Elboughdiri; Byong Hun Jeon; Yacine Benguerba

doi:10.1016/j.molliq.2022.119149

Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin

Oualid Alioui, Widad Sobhi, Matteo Tiecco, Inas M. Alnashef, Ayoub Attoui, Amel Boudechicha, Krishna Kumar Yadav, Ahmed M. Fallatah, Noureddine Elboughdiri, Byong Hun Jeon, Yacine Benguerba

Chemical and Petroleum Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Natural Deep Eutectic Solvents (NADESs) are a novel class of environmentally friendly liquids that can replace traditional organic solvents in industrial applications due to their ecologically beneficial features. These novel organic solvents are formed via weak interactions (mostly H-bonds) between two or more naturally existing substances. Even though they were recently found and recognized, NADESs have been the subject of significant and exciting research due to their unique properties. This study aims to determine the thermodynamic properties of eight NADESs and their solubility towards curcumin, a naturally occurring substance with significant medicinal properties. This study used a dual in-vitro and in-silico strategy: first, NADESs were characterized using Fourier transform infrared spectroscopy; second, various combinations and mixes were simulated using the Turbomole and COSMOThermX tools. Additionally, it was discovered that the curcumin activity coefficient in the NADES1 is −0.31 higher than that of the other NADESs (0.23–3.4) or the individual components (2.4–5.4) and water 8.9. The findings demonstrated that the studied NADESs had critical structural features in H-bonding and curcumin solubilization capabilities.

Original language	British English
Article number	119149
Journal	Journal of Molecular Liquids
Volume	359
DOIs	https://doi.org/10.1016/j.molliq.2022.119149
State	Published - 1 Aug 2022

Keywords

Choline Chloride
COSMO-RS
Curcumin
Deep Eutectic Solvents
Solubilization

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10.1016/j.molliq.2022.119149

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Alioui, O., Sobhi, W., Tiecco, M., Alnashef, I. M., Attoui, A., Boudechicha, A., Kumar Yadav, K., Fallatah, A. M., Elboughdiri, N., Jeon, B. H., & Benguerba, Y. (2022). Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin. Journal of Molecular Liquids, 359, Article 119149. https://doi.org/10.1016/j.molliq.2022.119149

@article{d871c74ab77c4c62aac0a12144fc0994,

title = "Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin",

abstract = "Natural Deep Eutectic Solvents (NADESs) are a novel class of environmentally friendly liquids that can replace traditional organic solvents in industrial applications due to their ecologically beneficial features. These novel organic solvents are formed via weak interactions (mostly H-bonds) between two or more naturally existing substances. Even though they were recently found and recognized, NADESs have been the subject of significant and exciting research due to their unique properties. This study aims to determine the thermodynamic properties of eight NADESs and their solubility towards curcumin, a naturally occurring substance with significant medicinal properties. This study used a dual in-vitro and in-silico strategy: first, NADESs were characterized using Fourier transform infrared spectroscopy; second, various combinations and mixes were simulated using the Turbomole and COSMOThermX tools. Additionally, it was discovered that the curcumin activity coefficient in the NADES1 is −0.31 higher than that of the other NADESs (0.23–3.4) or the individual components (2.4–5.4) and water 8.9. The findings demonstrated that the studied NADESs had critical structural features in H-bonding and curcumin solubilization capabilities.",

keywords = "Choline Chloride, COSMO-RS, Curcumin, Deep Eutectic Solvents, Solubilization",

author = "Oualid Alioui and Widad Sobhi and Matteo Tiecco and Alnashef, {Inas M.} and Ayoub Attoui and Amel Boudechicha and {Kumar Yadav}, Krishna and Fallatah, {Ahmed M.} and Noureddine Elboughdiri and Jeon, {Byong Hun} and Yacine Benguerba",

note = "Funding Information: Taif University research supporting Project number (TURSP-2020/46), Taif University, Taif, Saudi Arabia. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = aug,

day = "1",

doi = "10.1016/j.molliq.2022.119149",

language = "British English",

volume = "359",

journal = "Journal of Molecular Liquids",

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Alioui, O, Sobhi, W, Tiecco, M, Alnashef, IM, Attoui, A, Boudechicha, A, Kumar Yadav, K, Fallatah, AM, Elboughdiri, N, Jeon, BH & Benguerba, Y 2022, 'Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin', Journal of Molecular Liquids, vol. 359, 119149. https://doi.org/10.1016/j.molliq.2022.119149

TY - JOUR

T1 - Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin

AU - Alioui, Oualid

AU - Sobhi, Widad

AU - Tiecco, Matteo

AU - Alnashef, Inas M.

AU - Attoui, Ayoub

AU - Boudechicha, Amel

AU - Kumar Yadav, Krishna

AU - Fallatah, Ahmed M.

AU - Elboughdiri, Noureddine

AU - Jeon, Byong Hun

AU - Benguerba, Yacine

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Natural Deep Eutectic Solvents (NADESs) are a novel class of environmentally friendly liquids that can replace traditional organic solvents in industrial applications due to their ecologically beneficial features. These novel organic solvents are formed via weak interactions (mostly H-bonds) between two or more naturally existing substances. Even though they were recently found and recognized, NADESs have been the subject of significant and exciting research due to their unique properties. This study aims to determine the thermodynamic properties of eight NADESs and their solubility towards curcumin, a naturally occurring substance with significant medicinal properties. This study used a dual in-vitro and in-silico strategy: first, NADESs were characterized using Fourier transform infrared spectroscopy; second, various combinations and mixes were simulated using the Turbomole and COSMOThermX tools. Additionally, it was discovered that the curcumin activity coefficient in the NADES1 is −0.31 higher than that of the other NADESs (0.23–3.4) or the individual components (2.4–5.4) and water 8.9. The findings demonstrated that the studied NADESs had critical structural features in H-bonding and curcumin solubilization capabilities.

AB - Natural Deep Eutectic Solvents (NADESs) are a novel class of environmentally friendly liquids that can replace traditional organic solvents in industrial applications due to their ecologically beneficial features. These novel organic solvents are formed via weak interactions (mostly H-bonds) between two or more naturally existing substances. Even though they were recently found and recognized, NADESs have been the subject of significant and exciting research due to their unique properties. This study aims to determine the thermodynamic properties of eight NADESs and their solubility towards curcumin, a naturally occurring substance with significant medicinal properties. This study used a dual in-vitro and in-silico strategy: first, NADESs were characterized using Fourier transform infrared spectroscopy; second, various combinations and mixes were simulated using the Turbomole and COSMOThermX tools. Additionally, it was discovered that the curcumin activity coefficient in the NADES1 is −0.31 higher than that of the other NADESs (0.23–3.4) or the individual components (2.4–5.4) and water 8.9. The findings demonstrated that the studied NADESs had critical structural features in H-bonding and curcumin solubilization capabilities.

KW - Choline Chloride

KW - COSMO-RS

KW - Curcumin

KW - Deep Eutectic Solvents

KW - Solubilization

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U2 - 10.1016/j.molliq.2022.119149

DO - 10.1016/j.molliq.2022.119149

M3 - Article

AN - SCOPUS:85129704398

SN - 0167-7322

VL - 359

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

M1 - 119149

ER -

Theoretical and experimental evidence for the use of natural deep eutectic solvents to increase the solubility and extractability of curcumin

Abstract

Keywords

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