The Role of Functional Magnetic Resonance Imaging in the Study of Brain Development, Injury, and Recovery in the Newborn

Mohamed L. Seghier, Petra S. Hüppi

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Development of brain functions and the structural-functional correlates of brain injury remain difficult to evaluate in the young infant. Thus, new noninvasive methods capable of early functional diagnosis are needed. This review describes the use of functional magnetic resonance imaging (fMRI) for studying localization of brain function in the developing brain when standard clinical investigations are not available or conclusive. This promising neuroimaging technique has been successfully used in healthy newborns and in newborns with brain injury using different paradigms, including passive visual, somato-sensorial, and auditory stimulation. We summarize the major findings of previous fMRI studies in young infants, describe ongoing methodological challenges, and propose exciting future developments in using resting-state protocols and functional connectivity techniques to assist in evaluating early life brain function and its recovery from injury.

Original languageBritish English
Pages (from-to)79-86
Number of pages8
JournalSeminars in Perinatology
Volume34
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • abnormal function
  • BOLD response
  • brain injury
  • brain plasticity
  • functional MRI
  • newborn

Fingerprint

Dive into the research topics of 'The Role of Functional Magnetic Resonance Imaging in the Study of Brain Development, Injury, and Recovery in the Newborn'. Together they form a unique fingerprint.

Cite this