@article{c14ce6a2aaf44d409f3e8a2fe4b85dc4,
title = "The p.Arg435His variation of IgG3 with high affinity to FcRn is associated with susceptibility for pemphigus vulgaris-analysis of four different ethnic cohorts",
abstract = "IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the neonatal Fc receptor (FcRn). However, a few allelic variants harbor an amino acid replacement of His435 to Arg that reverts the half-life of the resulting IgG3 to the same level as the other IgG subclasses. Because of its functional impact, we hypothesized that the p.Arg435His variation could be associated with susceptibility to autoantibody-mediated diseases like pemphigus vulgaris (PV) and bullous pemphigoid (BP). Using a set of samples from German, Turkish, Egyptian, and Iranian patients and controls, we were able to demonstrate a genetic association of the p.Arg435His variation with PV risk, but not with BP risk. Our results suggest a hitherto unknown role for the function of IgG3 in the pathogenesis of PV.",
keywords = "Allotype, Autoantibodies, Dermatology, Functional genetics, Half-life, Immunology, Pemphigoid, Pemphigus",
author = "{the German AIBD Genetic Study Group} and Andreas Recke and Sarah Konitzer and Susanne Lemcke and Miriam Freitag and Sommer, {Nele Maxi} and Mohammad Abdelhady and Amoli, {Mahsa M.} and Sandrine Benoit and Farha El-Chennawy and Mohammad Eldarouti and R{\"u}diger Eming and Regine Gl{\"a}ser and Claudia G{\"u}nther and Eva Hadaschik and Bernhard Homey and Wolfgang Lieb and Peitsch, {Wiebke K.} and Claudia Pf{\"o}hler and Robati, {Reza M.} and Marjan Saeedi and Mikl{\'o}s S{\'a}rdy and Michael Sticherling and Soner Uzun and Margitta Worm and Detlef Zillikens and Saleh Ibrahim and Gestur Vidarsson and Enno Schmidt and Alexander Kreuter and Zouboulis, {Christos C.} and Georg D{\"a}schlein and Kerstin Steinbrink and Manfred Kunz and Nicolas Hunzelmann and Steven Goetze",
note = "Publisher Copyright: {\textcopyright} 2018 Recke, Konitzer, Lemcke, Freitag, Sommer, Abdelhady, Amoli, Benoit, El-Chennawy, Eldarouti, Eming, Gl{\"a}ser, G{\"u}nther, Hadaschik, Homey, Lieb, Peitsch, Pf{\"o}hler, Robati, Saeedi, S{\'a}rdy, Sticherling, Uzun, Worm, Zillikens, Ibrahim, Vidarsson, Schmidt and the German AIBD Genetic Study Group.",
year = "2018",
month = aug,
day = "2",
doi = "10.3389/fimmu.2018.01788",
language = "British English",
volume = "9",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media SA",
number = "AUG",
}