The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

Pejman Shojaee; Federica Mornata; Andreas Deutsch; Massimo Locati; Haralampos Hatzikirou

doi:10.3389/fimmu.2022.1050067

The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

Pejman Shojaee
, Federica Mornata
, Andreas Deutsch
, Massimo Locati
, Haralampos Hatzikirou

Mathematics

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.

Original language	British English
Article number	1050067
Journal	Frontiers in Immunology
Volume	13
DOIs	https://doi.org/10.3389/fimmu.2022.1050067
State	Published - 10 Nov 2022

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SDG 3 Good Health and Well-being

Keywords

cancer immunotherapy
mathematical modelling
tumor microenvironment (TME)
tumor-associated macrophage (TAM)
tumor-macrophage interactions

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title = "The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review",

abstract = "In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.",

keywords = "cancer immunotherapy, mathematical modelling, tumor microenvironment (TME), tumor-associated macrophage (TAM), tumor-macrophage interactions",

author = "Pejman Shojaee and Federica Mornata and Andreas Deutsch and Massimo Locati and Haralampos Hatzikirou",

note = "Funding Information: PS and HH have received funding from the Bundesministerium f{\"u}r Bildung, und Forschung (BMBF) under grant agreement No. 031L0237C (MiEDGE project/ERACOSYSMED). Moreover, HH and ML would like to acknowledge the support of the Volkswagenstiftung for “Life?” initiative (96732). HH acknowledges the support of the FSU grant 2021-2023 grant from Khalifa University. FM and ML have received funding from Ministero della Salute (MiEDGE project/ERACOSYSMED; Bando Ricerca Finalizzata RF-2019-12371549). Publisher Copyright: Copyright {\textcopyright} 2022 Shojaee, Mornata, Deutsch, Locati and Hatzikirou.",

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doi = "10.3389/fimmu.2022.1050067",

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T1 - The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling

T2 - A review

AU - Shojaee, Pejman

AU - Mornata, Federica

AU - Deutsch, Andreas

AU - Locati, Massimo

AU - Hatzikirou, Haralampos

N1 - Funding Information: PS and HH have received funding from the Bundesministerium für Bildung, und Forschung (BMBF) under grant agreement No. 031L0237C (MiEDGE project/ERACOSYSMED). Moreover, HH and ML would like to acknowledge the support of the Volkswagenstiftung for “Life?” initiative (96732). HH acknowledges the support of the FSU grant 2021-2023 grant from Khalifa University. FM and ML have received funding from Ministero della Salute (MiEDGE project/ERACOSYSMED; Bando Ricerca Finalizzata RF-2019-12371549). Publisher Copyright: Copyright © 2022 Shojaee, Mornata, Deutsch, Locati and Hatzikirou.

PY - 2022/11/10

Y1 - 2022/11/10

N2 - In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.

AB - In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.

KW - cancer immunotherapy

KW - mathematical modelling

KW - tumor microenvironment (TME)

KW - tumor-associated macrophage (TAM)

KW - tumor-macrophage interactions

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JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 1050067

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The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

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