The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

Pejman Shojaee, Federica Mornata, Andreas Deutsch, Massimo Locati, Haralampos Hatzikirou

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.

Original languageBritish English
Article number1050067
JournalFrontiers in Immunology
Volume13
DOIs
StatePublished - 10 Nov 2022

Keywords

  • cancer immunotherapy
  • mathematical modelling
  • tumor microenvironment (TME)
  • tumor-associated macrophage (TAM)
  • tumor-macrophage interactions

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