TY - JOUR
T1 - The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling
T2 - A review
AU - Shojaee, Pejman
AU - Mornata, Federica
AU - Deutsch, Andreas
AU - Locati, Massimo
AU - Hatzikirou, Haralampos
N1 - Funding Information:
PS and HH have received funding from the Bundesministerium für Bildung, und Forschung (BMBF) under grant agreement No. 031L0237C (MiEDGE project/ERACOSYSMED). Moreover, HH and ML would like to acknowledge the support of the Volkswagenstiftung for “Life?” initiative (96732). HH acknowledges the support of the FSU grant 2021-2023 grant from Khalifa University. FM and ML have received funding from Ministero della Salute (MiEDGE project/ERACOSYSMED; Bando Ricerca Finalizzata RF-2019-12371549).
Publisher Copyright:
Copyright © 2022 Shojaee, Mornata, Deutsch, Locati and Hatzikirou.
PY - 2022/11/10
Y1 - 2022/11/10
N2 - In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.
AB - In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.
KW - cancer immunotherapy
KW - mathematical modelling
KW - tumor microenvironment (TME)
KW - tumor-associated macrophage (TAM)
KW - tumor-macrophage interactions
UR - http://www.scopus.com/inward/record.url?scp=85142631588&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2022.1050067
DO - 10.3389/fimmu.2022.1050067
M3 - Review article
C2 - 36439180
AN - SCOPUS:85142631588
SN - 1664-3224
VL - 13
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1050067
ER -
