The i allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease

Antoine Abchee, Mirvat El-Sibai, Sonia Youhanna, Joumana S. Yeretzian, Hanine Estephan, Nadine J. Makhoul, Houry Puzantian, Jaber Sawaya, Antoine Nasrallah, Abdallah G. Rebeiz, Tony G. Zreik, Sami T. Azar, Pierre A. Zalloua

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic variants of the angiotensin converting enzyme (ACE), methytetrahydrofolate reductase, plasminogen activator inhibitor-1 and factor V genes and CAD. Methods: Clinical, biochemical, and angiographic information were collected from 300 patients who underwent cardiac catheterization and their DNA was genotyped by restriction fragment length polymorphism. Results: The frequency of the D allele of the ACE gene was significantly higher than the I allele in patients with more than 70% stenosis in any vessel. Among patients with more than 70% stenosis, carriers of the D allele were 2.8 times more likely to be males. The presence of the ACE I allele was negatively associated with CAD with (P=0.02 ,OR=0.38.) Conclusion: This study describes a protective role of the ACE I allele in individuals who may be at risk of developing CAD.

Original languageBritish English
Pages (from-to)151-156
Number of pages6
JournalCoronary Artery Disease
Volume21
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Angiotensin
  • Angiotensin converting enzyme
  • Coronary artery disease
  • Genotype
  • Polymorphisms

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