The effect of regular exercise on women receiving danazol for treatment of endometriosis

S. E. Carpenter, B. Tjaden, J. A. Rock, A. Kimball

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Objective: To determine the effects of regular exercise on women receiving danazol for the treatment of endometriosis. Methods: Thirty-nine patients were randomized to a danazol-only or a danazol/exercise regimen in a prospective clinical trial carried out at tertiary care institutions. Patients in the danazol/exercise group were instructed to exercise four times per week, for 40 min per session, at an intensity of 20 metabolic units. Side effect profiles, pelvic symptoms, aerobic fitness, strength and hormone levels were compared for all subjects. The number of side effects of danazol was analyzed by the method of generalized estimating equations. Results: The number of side effects reported during a 4-week period was 1.09-2.17 times greater for the danazol-only than for the danazol/exercise group. All patients had improvement of symptoms during treatment. The danazol/exercise group had significantly lower testosterone levels during treatment. The time to recurrence of endometriosis was not different between groups. Conclusions: Exercise during danazol therapy reduces the number of androgenic side effects. Relief of pain and time to recurrence are unaffected.

Original languageBritish English
Pages (from-to)299-304
Number of pages6
JournalInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Volume49
Issue number3
DOIs
StatePublished - Jun 1995

Keywords

  • Androgenic side effects
  • Danazol
  • Endometriosis
  • Exercise

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