The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes

Dietrich Lorke; Peter Möller

doi:10.1007/BF01884257

The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes

Dietrich Lorke, Peter Möller

College of Medicine and Health Sciences

University of Heidelberg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In order to study structural changes in the lymph node architecture in the course of metastatic involvent by carcinoma, 70 axillary lymph nodes of 45 female patients affected by breast carcinoma were examined. The follwing growth pattern of the metastasis was observed: (1) Involvement of vasa afferentia and (marginal) sinuses; (2) lysis of sinus wall and infiltration, causing replacement and lysis of reticulin fibres; (3) appearance of fibrillary fibronectin (FN) as the first noticeable sign of tumor stroma; (4) immigration of fibroblasts along these fibres, appearance of argyrophilic fibres codistributed with fibrillary FN; (5) formation of the complete tumor stroma, neovessels included. The appearance of FN is thus the first step of stroma formation and is interpreted as an "in situ" precipitation of soluble plasma FN.

Original language	British English
Pages (from-to)	65-71
Number of pages	7
Journal	Journal of Cancer Research and Clinical Oncology
Volume	109
Issue number	1
DOIs	https://doi.org/10.1007/BF01884257
State	Published - Feb 1985

Keywords

Breast carcinoma
Fibronectin
Immunperoxidase method
Lymph node metastasis

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10.1007/BF01884257

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title = "The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes",

abstract = "In order to study structural changes in the lymph node architecture in the course of metastatic involvent by carcinoma, 70 axillary lymph nodes of 45 female patients affected by breast carcinoma were examined. The follwing growth pattern of the metastasis was observed: (1) Involvement of vasa afferentia and (marginal) sinuses; (2) lysis of sinus wall and infiltration, causing replacement and lysis of reticulin fibres; (3) appearance of fibrillary fibronectin (FN) as the first noticeable sign of tumor stroma; (4) immigration of fibroblasts along these fibres, appearance of argyrophilic fibres codistributed with fibrillary FN; (5) formation of the complete tumor stroma, neovessels included. The appearance of FN is thus the first step of stroma formation and is interpreted as an {"}in situ{"} precipitation of soluble plasma FN.",

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T1 - The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes

AU - Lorke, Dietrich

AU - Möller, Peter

PY - 1985/2

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N2 - In order to study structural changes in the lymph node architecture in the course of metastatic involvent by carcinoma, 70 axillary lymph nodes of 45 female patients affected by breast carcinoma were examined. The follwing growth pattern of the metastasis was observed: (1) Involvement of vasa afferentia and (marginal) sinuses; (2) lysis of sinus wall and infiltration, causing replacement and lysis of reticulin fibres; (3) appearance of fibrillary fibronectin (FN) as the first noticeable sign of tumor stroma; (4) immigration of fibroblasts along these fibres, appearance of argyrophilic fibres codistributed with fibrillary FN; (5) formation of the complete tumor stroma, neovessels included. The appearance of FN is thus the first step of stroma formation and is interpreted as an "in situ" precipitation of soluble plasma FN.

AB - In order to study structural changes in the lymph node architecture in the course of metastatic involvent by carcinoma, 70 axillary lymph nodes of 45 female patients affected by breast carcinoma were examined. The follwing growth pattern of the metastasis was observed: (1) Involvement of vasa afferentia and (marginal) sinuses; (2) lysis of sinus wall and infiltration, causing replacement and lysis of reticulin fibres; (3) appearance of fibrillary fibronectin (FN) as the first noticeable sign of tumor stroma; (4) immigration of fibroblasts along these fibres, appearance of argyrophilic fibres codistributed with fibrillary FN; (5) formation of the complete tumor stroma, neovessels included. The appearance of FN is thus the first step of stroma formation and is interpreted as an "in situ" precipitation of soluble plasma FN.

KW - Breast carcinoma

KW - Fibronectin

KW - Immunperoxidase method

KW - Lymph node metastasis

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The early appearance of fibronectin in the course of metastatic tumor growth in lymph nodes

Abstract

Keywords

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