TY - JOUR
T1 - The controversial antibacterial activity of graphene-based materials
AU - Hegab, Hanaa M.
AU - Elmekawy, Ahmed
AU - Zou, Linda
AU - Mulcahy, Dennis
AU - Saint, Christopher P.
AU - Ginic-Markovic, Milena
N1 - Funding Information:
Hanaa Hegab appreciatively acknowledges the supportive funding from the Australian government and University of South Australia through an IPRS scholarship. Additionally, the authors would like to acknowledge the support of Water Research Australia.
Publisher Copyright:
© 2016 Elsevier Ltd. All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Graphene (Gr)-based materials are a promising nanomaterial for the development of antibacterial surfaces owing to their biocidal activity. However, the effect of the physicochemical features of these materials on their antibacterial activity has yet to be clarified. Gr-based nanomaterials can interact with cellular components, e.g. membranes, proteins and DNA, and initiate a sequence of nanomaterials/bacterial interactions that rely on colloidal energies and active bio-physicochemical interfaces. Analyzing these different interfaces permits the development of anticipated relations between physical/chemical structure and bactericidal activity depending on Gr-based nanomaterial features such as shape, size, hydrophilicity, roughness and functionality. Realizing how nanomaterials are interacting with bacterial cell membranes is correlated to how they affect bactericidal activity and is thus critical for obtaining benign applications. This review analytically discusses specific Gr-based material features related to bacterial interactions, with special focus on the different modes of interaction between Gr-based materials and cell membranes, nucleic acids and lipid bilayers.
AB - Graphene (Gr)-based materials are a promising nanomaterial for the development of antibacterial surfaces owing to their biocidal activity. However, the effect of the physicochemical features of these materials on their antibacterial activity has yet to be clarified. Gr-based nanomaterials can interact with cellular components, e.g. membranes, proteins and DNA, and initiate a sequence of nanomaterials/bacterial interactions that rely on colloidal energies and active bio-physicochemical interfaces. Analyzing these different interfaces permits the development of anticipated relations between physical/chemical structure and bactericidal activity depending on Gr-based nanomaterial features such as shape, size, hydrophilicity, roughness and functionality. Realizing how nanomaterials are interacting with bacterial cell membranes is correlated to how they affect bactericidal activity and is thus critical for obtaining benign applications. This review analytically discusses specific Gr-based material features related to bacterial interactions, with special focus on the different modes of interaction between Gr-based materials and cell membranes, nucleic acids and lipid bilayers.
UR - http://www.scopus.com/inward/record.url?scp=84968799908&partnerID=8YFLogxK
U2 - 10.1016/j.carbon.2016.04.046
DO - 10.1016/j.carbon.2016.04.046
M3 - Review article
AN - SCOPUS:84968799908
SN - 0008-6223
VL - 105
SP - 362
EP - 376
JO - Carbon
JF - Carbon
ER -