Tactile Awareness and Limb Position in Neglect: Functional Magnetic Resonance Imaging

Nathalie Valenza, Mohamed L. Seghier, Sophie Schwartz, François Lazeyras, Patrik Vuilleumier

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We studied a patient with right parietal damage for whom tactile stimuli on the right/ipsilesional hand (projecting to the intact left hemisphere) were extinguished from awareness during double simultaneous stimulation, when his right hand was positioned in the left/contralesional space. This demonstrates the role of an egocentric spatial reference frame in attention that can determine awareness of stimuli despite intact sensory pathways. Using functional magnetic resonance imaging to elucidate the neural correlates of such perceptual extinction, we found that limb position modulated neural responses to tactile stimuli at early cortical stages (SI) in the intact hemisphere. Activity in bilateral middle frontal gyri also was modulated by limb position and may contribute to integrate sensory inputs into a supramodal, egocentric representation of space.

Original languageBritish English
Pages (from-to)139-143
Number of pages5
JournalAnnals of Neurology
Volume55
Issue number1
DOIs
StatePublished - Jan 2004

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