T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh; Marc Haber; Angelique K. Salloum; Yasser Al-Sarraj; Yasmine Akle; Kamal Hirbli; Jihane Romanos; Francis Mouzaya; Dominique Gauguier; Daniel E. Platt; Hatem El-Shanti; Pierre A. Zalloua

doi:10.1038/srep07351

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Michella Ghassibe-Sabbagh
, Marc Haber
, Angelique K. Salloum
, Yasser Al-Sarraj
, Yasmine Akle
, Kamal Hirbli
, Jihane Romanos
, Francis Mouzaya
, Dominique Gauguier
, Daniel E. Platt
, Hatem El-Shanti
, Pierre A. Zalloua

College of Medicine and Health Sciences

Lebanese American University
Shafallah Medical Genetics Center
Centre Hospitalier du Nord-CHN
Lebanese American University Medical Center-Rizk Hospital
Centre de Recherche des Cordeliers
IBM T. J. Watson Research Centre
University of Iowa College of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10^-9) and rs34872471 (OR = 1.35, P = 1.01 × 10^-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

Original language	British English
Article number	7351
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep07351
State	Published - 2014

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title = "T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility",

abstract = "Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.",

author = "Michella Ghassibe-Sabbagh and Marc Haber and Salloum, \{Angelique K.\} and Yasser Al-Sarraj and Yasmine Akle and Kamal Hirbli and Jihane Romanos and Francis Mouzaya and Dominique Gauguier and Platt, \{Daniel E.\} and Hatem El-Shanti and Zalloua, \{Pierre A.\}",

note = "Funding Information: We thank the patients for agreeing to participate in the study. We thank Dr. Bouchra Douaihy and Mrs. Hana Sbeite for helping in the campaigns. We thank the dispensaire de la maison maronite de soins et d{\textquoteright}h{\'e}bergement-Ain El Remmaneh, Ehden Governmental Hospital - Ehden, Caritas Liban - Dahr el Ain, Lebanese Red Cross - Amioun, Saint Joseph dispensary - Zgharta, and dispensary of Kfarhabou –Donnieh for hosting the campaigns. This publication was made possible by a grant from the Qatar National Research Fund under its National Priorities Research program (NPRP) award number NPRP 09-215-3-049. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Qatar National Research Fund.",

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doi = "10.1038/srep07351",

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AU - Ghassibe-Sabbagh, Michella

AU - Haber, Marc

AU - Salloum, Angelique K.

AU - Al-Sarraj, Yasser

AU - Akle, Yasmine

AU - Hirbli, Kamal

AU - Romanos, Jihane

AU - Mouzaya, Francis

AU - Gauguier, Dominique

AU - Platt, Daniel E.

AU - El-Shanti, Hatem

AU - Zalloua, Pierre A.

N1 - Funding Information: We thank the patients for agreeing to participate in the study. We thank Dr. Bouchra Douaihy and Mrs. Hana Sbeite for helping in the campaigns. We thank the dispensaire de la maison maronite de soins et d’hébergement-Ain El Remmaneh, Ehden Governmental Hospital - Ehden, Caritas Liban - Dahr el Ain, Lebanese Red Cross - Amioun, Saint Joseph dispensary - Zgharta, and dispensary of Kfarhabou –Donnieh for hosting the campaigns. This publication was made possible by a grant from the Qatar National Research Fund under its National Priorities Research program (NPRP) award number NPRP 09-215-3-049. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Qatar National Research Fund.

PY - 2014

Y1 - 2014

N2 - Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

AB - Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

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JO - Scientific Reports

JF - Scientific Reports

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ER -

T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Abstract

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