Synthesis of tetradentate schiff base derivatives of transition bimetallic complexes as antimicrobial agents

Muhammad Yousaf, Muhammad Pervaiz, Muhammad Sagir, Ashhar-Uz-Zaman, Muhammad Mushtaq, Muhammad Yasin Naz

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    A series of Co(II), Cu(II), Mn(II) and Zn(II) bimetallic complexes have been synthesized with the schiff base ligand 2-(bis-2-hydroxyl phenylidene) diimine (L) derived from the condensation of hydrazine and salicylaldehyde. The synthesized ligand and bimetallic complexes were characterized by different spectroscopic techniques. The characterization of ligand was carried out by FT-IR, H1NMR, C13NMR andMS while the bimetallic complexes were characterized by FT-IR and X-ray crystallographic techniques. The complexes and ligand were employed in vitro for antifungal and antibacterial activities using disc diffusion method. Different fungal strains such as Alternaria Alternate, Aspergillus Flavus and Aspergillus Niger were used to check antifungal activities of bimetallic complexes and ligand. Similarly, the bacterial strains used were Staphylococcus Aureus, Bacillus Subbtilis and Escheria Coli. The biological studies showed that the ligand exhibited lower value of antifungal and antibacterial activities than bimetallic complexes.

    Original languageBritish English
    Pages (from-to)1150-1155
    Number of pages6
    JournalJournal of the Chinese Chemical Society
    Volume60
    Issue number9
    DOIs
    StatePublished - Sep 2013

    Keywords

    • Bacterial strains
    • Fungal strains.
    • Hydrazine
    • Salicylaldehyde
    • Schiff base
    • Transition metals

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