TY - JOUR
T1 - Synthesis of MnO2 decorated mesoporous carbon nanocomposite for electrocatalytic detection of antifungal drug
AU - Arumugam, Balamurugan
AU - Nagarajan, Vimalasundari
AU - Annaraj, Jamespandi
AU - Balasubramanian, Kavitha
AU - Palanisamy, Selvakumar
AU - Ramaraj, Sayee Kannan
AU - Chiesa, Matteo
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/11
Y1 - 2022/11
N2 - In this study, manganese oxide tailored mesoporous carbon materials (MnO2/MC) were synthesized through a hydrothermal method. An electrode modified with MnO2/MC was used to detect the antifungal drug Iodochlorohydroxyquin (ICQ) with improved sensitivity. Synergistic interactions between the metal oxide and carbon-based material significantly improve specific properties of the prepared nanocomposite, such as excellent conductivity, high electron transfer rate, numerous active sites, and electron transport networks. An electroanalytical analysis revealed that the MnO2/MC electrocatalyst showed excellent electrochemical activity for the determination of ICQ. It exposes a dynamic response range of 0.01–1010 μM with a low level of detection of 0.001 μM and superior sensitivity of 3.48 μAμM−1cm−2. The proposed sensor exhibits significant selectivity, outstanding reproducibility, and stability. Also, ICQ has been determined in pharmaceutical tablets and human urine using the fabricated MnO2/MC electrode.
AB - In this study, manganese oxide tailored mesoporous carbon materials (MnO2/MC) were synthesized through a hydrothermal method. An electrode modified with MnO2/MC was used to detect the antifungal drug Iodochlorohydroxyquin (ICQ) with improved sensitivity. Synergistic interactions between the metal oxide and carbon-based material significantly improve specific properties of the prepared nanocomposite, such as excellent conductivity, high electron transfer rate, numerous active sites, and electron transport networks. An electroanalytical analysis revealed that the MnO2/MC electrocatalyst showed excellent electrochemical activity for the determination of ICQ. It exposes a dynamic response range of 0.01–1010 μM with a low level of detection of 0.001 μM and superior sensitivity of 3.48 μAμM−1cm−2. The proposed sensor exhibits significant selectivity, outstanding reproducibility, and stability. Also, ICQ has been determined in pharmaceutical tablets and human urine using the fabricated MnO2/MC electrode.
KW - Antifungal drugs
KW - Electrochemical sensor
KW - Iodochlorohydroxyquin
KW - Mesoporous carbon
KW - MnO
UR - http://www.scopus.com/inward/record.url?scp=85138542606&partnerID=8YFLogxK
U2 - 10.1016/j.microc.2022.107891
DO - 10.1016/j.microc.2022.107891
M3 - Article
AN - SCOPUS:85138542606
SN - 0026-265X
VL - 182
JO - Microchemical Journal
JF - Microchemical Journal
M1 - 107891
ER -