Synthesis of MnO2 decorated mesoporous carbon nanocomposite for electrocatalytic detection of antifungal drug

Balamurugan Arumugam, Vimalasundari Nagarajan, Jamespandi Annaraj, Kavitha Balasubramanian, Selvakumar Palanisamy, Sayee Kannan Ramaraj, Matteo Chiesa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In this study, manganese oxide tailored mesoporous carbon materials (MnO2/MC) were synthesized through a hydrothermal method. An electrode modified with MnO2/MC was used to detect the antifungal drug Iodochlorohydroxyquin (ICQ) with improved sensitivity. Synergistic interactions between the metal oxide and carbon-based material significantly improve specific properties of the prepared nanocomposite, such as excellent conductivity, high electron transfer rate, numerous active sites, and electron transport networks. An electroanalytical analysis revealed that the MnO2/MC electrocatalyst showed excellent electrochemical activity for the determination of ICQ. It exposes a dynamic response range of 0.01–1010 μM with a low level of detection of 0.001 μM and superior sensitivity of 3.48 μAμM−1cm−2. The proposed sensor exhibits significant selectivity, outstanding reproducibility, and stability. Also, ICQ has been determined in pharmaceutical tablets and human urine using the fabricated MnO2/MC electrode.

Original languageBritish English
Article number107891
JournalMicrochemical Journal
Volume182
DOIs
StatePublished - Nov 2022

Keywords

  • Antifungal drugs
  • Electrochemical sensor
  • Iodochlorohydroxyquin
  • Mesoporous carbon
  • MnO

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