Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

Jedidiah Whitt; Cameron Duke; Mohamad Akbar Ali; Steven A. Chambers; Md Mahbub Kabir Khan; David Gilmore; Mohammad A. Alam

doi:10.1021/acsomega.9b01967

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

Jedidiah Whitt
, Cameron Duke
, Mohamad Akbar Ali
, Steven A. Chambers
, Md Mahbub Kabir Khan
, David Gilmore
, Mohammad A. Alam

Chemistry

Arkansas State University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

Original language	British English
Pages (from-to)	14284-14293
Number of pages	10
Journal	ACS Omega
Volume	4
Issue number	10
DOIs	https://doi.org/10.1021/acsomega.9b01967
State	Published - 3 Sep 2019

Access to Document

10.1021/acsomega.9b01967

OpenUrl availability

Full text

Fingerprint

Dive into the research topics of 'Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria'. Together they form a unique fingerprint.

Cite this

Whitt, J., Duke, C., Ali, M. A., Chambers, S. A., Khan, M. M. K., Gilmore, D., & Alam, M. A. (2019). Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria. ACS Omega, 4(10), 14284-14293. https://doi.org/10.1021/acsomega.9b01967

@article{0c938f468b814e96aa2be03e4eec8a8d,

title = "Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria",

abstract = "Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.",

author = "Jedidiah Whitt and Cameron Duke and Ali, \{Mohamad Akbar\} and Chambers, \{Steven A.\} and Khan, \{Md Mahbub Kabir\} and David Gilmore and Alam, \{Mohammad A.\}",

note = "Funding Information: This publication was made possible by the Arkansas INBRE program, supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429 from the National Institutes of Health. ABI mini-grant 200136 also helped to complete this manuscript. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = sep,

day = "3",

doi = "10.1021/acsomega.9b01967",

language = "British English",

volume = "4",

pages = "14284--14293",

journal = "ACS Omega",

issn = "2470-1343",

publisher = "American Chemical Society",

number = "10",

}

Whitt, J, Duke, C, Ali, MA, Chambers, SA, Khan, MMK, Gilmore, D & Alam, MA 2019, 'Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria', ACS Omega, vol. 4, no. 10, pp. 14284-14293. https://doi.org/10.1021/acsomega.9b01967

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria. / Whitt, Jedidiah; Duke, Cameron; Ali, Mohamad Akbar et al.
In: ACS Omega, Vol. 4, No. 10, 03.09.2019, p. 14284-14293.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

AU - Whitt, Jedidiah

AU - Duke, Cameron

AU - Ali, Mohamad Akbar

AU - Chambers, Steven A.

AU - Khan, Md Mahbub Kabir

AU - Gilmore, David

AU - Alam, Mohammad A.

N1 - Funding Information: This publication was made possible by the Arkansas INBRE program, supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429 from the National Institutes of Health. ABI mini-grant 200136 also helped to complete this manuscript. Publisher Copyright: Copyright © 2019 American Chemical Society.

PY - 2019/9/3

Y1 - 2019/9/3

N2 - Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

AB - Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

UR - https://www.scopus.com/pages/publications/85071721428

U2 - 10.1021/acsomega.9b01967

DO - 10.1021/acsomega.9b01967

M3 - Article

AN - SCOPUS:85071721428

SN - 2470-1343

VL - 4

SP - 14284

EP - 14293

JO - ACS Omega

JF - ACS Omega

IS - 10

ER -

Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

Abstract

Access to Document

OpenUrl availability

Other files and links

Fingerprint

Cite this