Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria

Jedidiah Whitt, Cameron Duke, Mohamad Akbar Ali, Steven A. Chambers, Md Mahbub Kabir Khan, David Gilmore, Mohammad A. Alam

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.

Original languageBritish English
Pages (from-to)14284-14293
Number of pages10
JournalACS Omega
Volume4
Issue number10
DOIs
StatePublished - 3 Sep 2019

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