@article{0c938f468b814e96aa2be03e4eec8a8d,
title = "Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria",
abstract = "Microbial resistance to antibiotics is an urgent and worldwide concern. Several pyrazole-derived hydrazones were synthesized by using benign reaction conditions. Several of these molecules are potent growth inhibitors of drug-resistant strains of Staphylococcus aureus and Acinetobacter baumannii with minimum inhibitory concentration values as low as 0.39 μg/mL. Furthermore, these molecules are nontoxic to human cells at high concentrations. Some of these molecules were tested for their ability to disrupt the bacterial membrane by using the SYTO-9/propidium iodide (BacLight) assay.",
author = "Jedidiah Whitt and Cameron Duke and Ali, {Mohamad Akbar} and Chambers, {Steven A.} and Khan, {Md Mahbub Kabir} and David Gilmore and Alam, {Mohammad A.}",
note = "Funding Information: This publication was made possible by the Arkansas INBRE program, supported by a grant from the National Institute of General Medical Sciences, (NIGMS), P20 GM103429 from the National Institutes of Health. ABI mini-grant 200136 also helped to complete this manuscript. Publisher Copyright: Copyright {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = sep,
day = "3",
doi = "10.1021/acsomega.9b01967",
language = "British English",
volume = "4",
pages = "14284--14293",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "American Chemical Society",
number = "10",
}