@article{3c7791e9322c4b47a38328c4c12de8e0,
title = "Synergistic Catalysis: Highly Enantioselective Cascade Reaction for the Synthesis of Dihydroacridines",
abstract = "The first stereoselective synthesis of dihydroacridines through synergistic catalysis, achieving the final target compounds with good to excellent yields and good to excellent enantioselectivities and diastereoselectivities, is reported. The synergistic approach consists in the activation of substituted quinolines with a Lewis acid catalyst that react in a cascade fashion with activated enals in the iminium form. Mechanistic calculations support a consecutive Michael–aldol reaction, followed by dehydration.",
keywords = "acridine, diastereoselective, enantioselective, synergistic catalysis, ytterbium",
author = "Sara Meninno and Marta Meazza and Yang, {Jung Woon} and Tomas Tejero and Pedro Merino-Gomez and Ramon Rios",
note = "Funding Information: S.M. and R.R. thank Accademia Nazionale dei Lincei for the RSC fellowship. M.M. and R.R. are grateful for EPSRC Core Capability Funding (EP/K039466/1). R.R. thanks Stephane Bidou, George Tsatsamis-Cooper and Andrew Howe for preliminary tests. T.T. and P.M. acknowledge the MINECO and FEDER Program (Madrid, Spain, project CTQ2016-76155-R) and the Gobierno de Arag{\'o}n (Zaragoza, Spain. Biological and Computational Chemistry Group. E-34_17R). The authors thankfully acknowledge the resources from the supercomputers “Memento” and “Cierzo”, technical expertise and assistance provided by BIFI-ZCAM (Universidad de Zaragoza, Spain). Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jun,
day = "7",
doi = "10.1002/chem.201901498",
language = "British English",
volume = "25",
pages = "7623--7627",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "John Wiley and Sons Inc.",
number = "32",
}