@article{49fe24a84de749f2b7c4b944ccd4c8e4,
title = "Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals",
abstract = "A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal{\textendash}Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations.",
keywords = "acetyl aza-arenes, enals, Michael addition, secondary amine catalysis, synergistic catalysis",
author = "Marta Meazza and Gabriela Sitinova and Cecilia Poderi and Michele Mancinelli and Kaiheng Zhang and Andrea Mazzanti and Torres, \{Ramon Rios\}",
note = "Funding Information: Abstract: A novel catalytic enantioselective methodology based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy in- volves the metal{\textendash}Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations. Funding Information: M.M. and R.R are grateful for EPSRC Core Capability Funding (EP/K039466/1). Financial contribution was received by A.M., M.M., and C.P. from the University of Bologna (RFO funds 2015 and 2016). Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",
year = "2018",
month = sep,
day = "6",
doi = "10.1002/chem.201802303",
language = "British English",
volume = "24",
pages = "13306--13310",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "John Wiley and Sons Inc.",
number = "50",
}