Synergistic catalysis: Enantioselective addition of Alkylbenzoxazoles to Enals

Marta Meazza, Victor Ceban, Mateusz B. Pitak, Simon J. Coles, Ramon Rios

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.

Original languageBritish English
Pages (from-to)16853-16857
Number of pages5
JournalChemistry - A European Journal
Volume20
Issue number51
DOIs
StatePublished - 15 Dec 2014

Keywords

  • alkyl azaarenes
  • Iminium catalysis
  • Michael addition
  • Palladium
  • Synergistic catalysis

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