Synergistic Catalysis: Asymmetric Synthesis of Cyclopentanes Bearing Four Stereogenic Centers

Kaiheng Zhang, Marta Meazza, Anabel Izaga, Clotilde Contamine, M. Concepción Gimeno, Raquel P. Herrera, Ramon Rios

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

We present a formal [3+2] cycloaddition based on synergistic catalysis. Vinylcyclopropanes derived from cyanoesters react with enals by dual activation using palladium(0) and secondary amines to form the corresponding cyclopentanes in good yields and stereoselectivities.

Original languageBritish English
Article numberss-2016-z0674-op
Pages (from-to)167-174
Number of pages8
JournalSynthesis
Volume49
Issue number1
DOIs
StatePublished - 3 Jan 2017

Keywords

  • asymmetric synthesis
  • cycloaddition
  • cyclopentanes
  • organocatalysis
  • synergistic catalysis

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