Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels

Jiezhou Pan; Haotian Liao; Guidong Gong; Yunxiang He; Qin Wang; Lang Qin; Yaoyao Zhang; Hirotaka Ejima; Blaise L. Tardy; Joseph J. Richardson; Jiaojiao Shang; Orlando J. Rojas; Yong Zeng; Junling Guo

doi:10.1016/j.jconrel.2023.07.003

Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels

Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Drug-dependent design of hydrogels is currently required for engineering the controlled release of therapeutics, which is a major contributor to the technical challenges relating to the clinical translation of hydrogel-drug systems. Herein, by integrating supramolecular phenolic-based nanofillers (SPFs) into hydrogel microstructures we developed a facile strategy to endow a range of clinically relevant hydrogels with controlled release properties for diverse therapeutic agents. The assembly of multiscale SPF aggregates leads to tunable mesh size and multiple dynamic interactions between SPF aggregates and drugs, which relaxes the available choices of drugs and hydrogels. This simple approach allowed for the controlled release of 12 representative drugs evaluated with 8 commonly used hydrogels. Moreover, the anesthetic drug lidocaine was loaded into SPF-integrated alginate hydrogel and demonstrated sustained release for 14 days in vivo, validating the potential for long-term anesthesia in patients.

Original language	British English
Pages (from-to)	433-446
Number of pages	14
Journal	Journal of Controlled Release
Volume	360
DOIs	https://doi.org/10.1016/j.jconrel.2023.07.003
State	Published - Aug 2023

Keywords

Diffusion kinetics
Drug controlled release
Dynamic interactions
Hydrogel
Metal-phenolic nanofiller

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2023.07.003

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Pan, J., Liao, H., Gong, G., He, Y., Wang, Q., Qin, L., Zhang, Y., Ejima, H., Tardy, B. L., Richardson, J. J., Shang, J., Rojas, O. J., Zeng, Y., & Guo, J. (2023). Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. Journal of Controlled Release, 360, 433-446. https://doi.org/10.1016/j.jconrel.2023.07.003

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title = "Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels",

abstract = "Drug-dependent design of hydrogels is currently required for engineering the controlled release of therapeutics, which is a major contributor to the technical challenges relating to the clinical translation of hydrogel-drug systems. Herein, by integrating supramolecular phenolic-based nanofillers (SPFs) into hydrogel microstructures we developed a facile strategy to endow a range of clinically relevant hydrogels with controlled release properties for diverse therapeutic agents. The assembly of multiscale SPF aggregates leads to tunable mesh size and multiple dynamic interactions between SPF aggregates and drugs, which relaxes the available choices of drugs and hydrogels. This simple approach allowed for the controlled release of 12 representative drugs evaluated with 8 commonly used hydrogels. Moreover, the anesthetic drug lidocaine was loaded into SPF-integrated alginate hydrogel and demonstrated sustained release for 14 days in vivo, validating the potential for long-term anesthesia in patients.",

keywords = "Diffusion kinetics, Drug controlled release, Dynamic interactions, Hydrogel, Metal-phenolic nanofiller",

author = "Jiezhou Pan and Haotian Liao and Guidong Gong and Yunxiang He and Qin Wang and Lang Qin and Yaoyao Zhang and Hirotaka Ejima and Tardy, {Blaise L.} and Richardson, {Joseph J.} and Jiaojiao Shang and Rojas, {Orlando J.} and Yong Zeng and Junling Guo",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",

year = "2023",

month = aug,

doi = "10.1016/j.jconrel.2023.07.003",

language = "British English",

volume = "360",

pages = "433--446",

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T1 - Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels

AU - Pan, Jiezhou

AU - Liao, Haotian

AU - Gong, Guidong

AU - He, Yunxiang

AU - Wang, Qin

AU - Qin, Lang

AU - Zhang, Yaoyao

AU - Ejima, Hirotaka

AU - Tardy, Blaise L.

AU - Richardson, Joseph J.

AU - Shang, Jiaojiao

AU - Rojas, Orlando J.

AU - Zeng, Yong

AU - Guo, Junling

PY - 2023/8

Y1 - 2023/8

N2 - Drug-dependent design of hydrogels is currently required for engineering the controlled release of therapeutics, which is a major contributor to the technical challenges relating to the clinical translation of hydrogel-drug systems. Herein, by integrating supramolecular phenolic-based nanofillers (SPFs) into hydrogel microstructures we developed a facile strategy to endow a range of clinically relevant hydrogels with controlled release properties for diverse therapeutic agents. The assembly of multiscale SPF aggregates leads to tunable mesh size and multiple dynamic interactions between SPF aggregates and drugs, which relaxes the available choices of drugs and hydrogels. This simple approach allowed for the controlled release of 12 representative drugs evaluated with 8 commonly used hydrogels. Moreover, the anesthetic drug lidocaine was loaded into SPF-integrated alginate hydrogel and demonstrated sustained release for 14 days in vivo, validating the potential for long-term anesthesia in patients.

AB - Drug-dependent design of hydrogels is currently required for engineering the controlled release of therapeutics, which is a major contributor to the technical challenges relating to the clinical translation of hydrogel-drug systems. Herein, by integrating supramolecular phenolic-based nanofillers (SPFs) into hydrogel microstructures we developed a facile strategy to endow a range of clinically relevant hydrogels with controlled release properties for diverse therapeutic agents. The assembly of multiscale SPF aggregates leads to tunable mesh size and multiple dynamic interactions between SPF aggregates and drugs, which relaxes the available choices of drugs and hydrogels. This simple approach allowed for the controlled release of 12 representative drugs evaluated with 8 commonly used hydrogels. Moreover, the anesthetic drug lidocaine was loaded into SPF-integrated alginate hydrogel and demonstrated sustained release for 14 days in vivo, validating the potential for long-term anesthesia in patients.

KW - Diffusion kinetics

KW - Drug controlled release

KW - Dynamic interactions

KW - Hydrogel

KW - Metal-phenolic nanofiller

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U2 - 10.1016/j.jconrel.2023.07.003

DO - 10.1016/j.jconrel.2023.07.003

M3 - Article

C2 - 37422124

AN - SCOPUS:85164265917

SN - 0168-3659

VL - 360

SP - 433

EP - 446

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels

Abstract

Keywords

UN SDGs

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