Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC®

Nathalie Bernoud-Hubac; Mayssa Hachem; Amanda Lo Van; Madeleine Picq; Michel Lagarde

doi:10.1051/ocl/2016053

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC^®

Nathalie Bernoud-Hubac, Mayssa Hachem, Amanda Lo Van, Madeleine Picq, Michel Lagarde

Chemistry

INSA Lyon

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA). AceDoPC^® is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC^® is a specific and preferred carrier of DHA to the brain. When AceDoPC^® was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

Original language	British English
Article number	D205
Journal	OCL - Oilseeds and fats, Crops and Lipids
Volume	24
Issue number	2
DOIs	https://doi.org/10.1051/ocl/2016053
State	Published - 1 Mar 2017

Keywords

AceDoPC
Blood-brain barrier
Brain
Docosahexaenoic acid
Lysophosphatidylcholine
Transport

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10.1051/ocl/2016053

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title = "Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC{\textregistered}",

abstract = "Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA). AceDoPC{\textregistered} is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC{\textregistered} is a specific and preferred carrier of DHA to the brain. When AceDoPC{\textregistered} was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.",

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AU - Hachem, Mayssa

AU - Lo Van, Amanda

AU - Picq, Madeleine

AU - Lagarde, Michel

N1 - Publisher Copyright: © N. Bernoud-Hubac et al.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA). AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® is a specific and preferred carrier of DHA to the brain. When AceDoPC® was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

AB - Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. Findings suggested that DHA is better incorporated into the brain when esterified at the sn-2 position of a lysophosphatidylcholine (LysoPC-DHA). AceDoPC® is a structured phospholipid or acetyl-LysoPC-DHA. As previously shown for LysoPC-DHA, AceDoPC® is a specific and preferred carrier of DHA to the brain. When AceDoPC® was injected to rats that were subjected to an ischemic stroke, it prevents the extension of brain lesions. Regarding the essential role of DHA for cerebral functions, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

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KW - Blood-brain barrier

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KW - Lysophosphatidylcholine

KW - Transport

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ER -

Specific uptake of DHA by the brain from a structured phospholipid, AceDoPC^®

Abstract

Keywords

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