Somatostatin immunoreactivity in bone and joint tissues

Adlan M. Elhassan, Abdu Adem, K. Hultenby, J. U. Lindgren

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Using immunoelectron microscopy we have investigated the presence of somatostatin in normal bone and joint tissues. We observed somatostatin labeling in the myelinated nerve fibers of the periosteum, the bone marrow cells and in the mature bone matrix but only slightly in the synovial cells. Quantification of somatostatin in bone tissue by radioimmunoassay showed highest levels in bone marrow followed by periosteum and cortical bone. These findings suggest a role for somatostatin in bone and joint physiology.

Original languageBritish English
Pages (from-to)2573-2575
Number of pages3
Issue number11
StatePublished - 3 Aug 1998


  • Bone
  • Myelinated nerve
  • Periosteum
  • Somatostatin


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