Sindrome de Ohtahara

Translated title of the contribution: Ohtahara syndrome

K. Yelin, I. Alfonso, O. Papazian

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Introduction. A literature review using the term Ohtahara syndrome and early infantile epileptic encephalopathy revealed 51 cases. Development. The characteristics of these cases were: 1) early onset of seizures; 2) tonic seizures; 3) poor response to treatment; 4) mental retardation; 5) poor prognosis; 6) burst-suppression EEG pattern; 7) evolution to West syndrome, and 8) multiple causes. These characteristics are non specific. No cause was found in most cases. The onset of seizures was between 7 hours and 86 days of age. The most frequent brain imaging abnormality was diffuse atrophy. ACTH was effective in a few cases and hemispherectomy was successful in one case. Conclusion. We believe that Ohtahara syndrome and early myoclonic encephalopathy are the same entity.

Translated title of the contributionOhtahara syndrome
Original languageSpanish
Pages (from-to)340-342
Number of pages3
JournalRevista de Neurologia
Issue number4
StatePublished - 16 Aug 1999


  • Epileptic encephalopathy
  • Neonatal seizures
  • Ohtahara syndrome
  • Suppression-burst


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