Signal peptide prediction in single transmembrane proteins using the continuous wavelet transform

I. A. Avramidou, I. K. Kitsas, L. J. Hadjileontiadis

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The signal peptide (SP) is directly associated with a protein's translocation across biological membranes and consequently with the expression of its functional role. A scheme of predicting the exact position of the SP within a protein is proposed in this work, by applying the continuous wavelet transform (CWT) to the hydrophobic sequence of the protein. The scheme was developed with regard to proteins of known structure extracted from public available databases. The results have verified the effectiveness of the method, which is comparable to existing methods, thus revealing a novel and fast approach to the prediction of SP in single transmembrane proteins, with a prospect of a generalized application.

Original languageBritish English
Title of host publicationXII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010
Pages65-68
Number of pages4
DOIs
StatePublished - 2010
Event12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 - Chalkidiki, Greece
Duration: 27 May 201030 May 2010

Publication series

NameIFMBE Proceedings
Volume29
ISSN (Print)1680-0737

Conference

Conference12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010
Country/TerritoryGreece
CityChalkidiki
Period27/05/1030/05/10

Keywords

  • continuous wavelet transform
  • prediction
  • proteins
  • Signal peptide
  • transmembrane

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