Shape matters: The diffusion rates of TMV rods and CPMV icosahedrons in a spheroid model of extracellular matrix are distinct

Karin L. Lee, Logan C. Hubbard, Stephen Hern, Ibrahim Yildiz, Miklos Gratzl, Nicole F. Steinmetz

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Nanomaterial-based carrier systems hold great promise to deliver therapies with increased efficacy and reduced side effects. While the state-of-the-art carrier system is a sphere, recent data indicate that elongated rods and filaments have advantageous flow and margination properties, resulting in enhanced vascular targeting and tumor homing. Here, we report on the distinct diffusion rates of two bio-inspired carrier systems: 30 nm-sized spherical cowpea mosaic virus (CPMV) and 300 × 18 nm-sized tobacco mosaic virus (TMV) with a tubular structure, using a spheroid model of the tumor microenvironment and fluorescent imaging.

Original languageBritish English
Pages (from-to)581-588
Number of pages8
JournalBiomaterials Science
Volume1
Issue number6
DOIs
StatePublished - Jun 2013

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