Shape-controlled rapid synthesis of magnetic nanoparticles and their morphological dependent magnetic and thermal studies for cancer therapy applications

Bi-metallic Ni₅₀Co₅₀ magnetic alloy nanoparticles (MANPs) with controllable shape (rhombus, pentagon and sphere) have been developed through microwave technology for the first time using water and ethylene glycol as solvents. The formation mechanism, morphology evaluation, crystalline structure, and morphological dependent magnetic property have been investigated. The pentagonal-like Ni₅₀Co₅₀ MANPs shows a higher magnetization (M_s-101 emu g^-1) and higher coercivity (H_c-550 Oe) than rhombus and sphere-like samples. The cell viability MTT assay studies exhibited the biocompatibility nature of the prepared Ni₅₀Co₅₀ MANPs. Moreover, morphological dependent magnetic induction heating properties of the Ni₅₀Co₅₀ MANPs samples were estimated under an alternating magnetic field (AMF) of 190 kHz. The heating ability of pentagon-like Ni₅₀Co₅₀ MANPs up to 42 °C and specific absorption rate (SAR) of 59 W g^-1 at reasonably low concentrations highlighted the suitability of the Ni₅₀Co₅₀ MANPs for hyperthermia applications. This study demonstrated that the Ni₅₀Co₅₀ MANPs with different shape can be used as an ideal building block for hyperthermia applications.