Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels

D. A. Akkad, L. Arning, S. M. Ibrahim, J. T. Epplen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The interleukin 4 promoter polymorphism -589 C/T (rs2243250) was genotyped in 869 multiple sclerosis (MS) patients and 595 healthy blood donors. Sex-specific MS association was evident whereas two flanking polymorphisms showed insignificant P values. In dual luciferase assays of cultured Jurkat cells the cloned promoter comprising the -589 T allele leads to higher expression as compared to the respective construct with the C allele. Together these findings may be discussed functionally as contributing to the genetic predisposition and to the pathogenesis in MS.

Original languageBritish English
Pages (from-to)703-706
Number of pages4
JournalGenes and Immunity
Volume8
Issue number8
DOIs
StatePublished - Dec 2007

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