Selective induction of glutathione S-transferase D in rat testis by phenobarbital

D. Sheehan; C. M. Ryle; T. J. Mantle

doi:10.1042/bj2190687

Selective induction of glutathione S-transferase D in rat testis by phenobarbital

D. Sheehan
, C. M. Ryle
, T. J. Mantle

Chemistry

Trinity College Dublin

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Testis cytosol is shown to contain the Yb₂Yb₂-homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A(Yb₁Yb₁) and C (Yb₁Yb₂). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb₂ subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb₁ subunit.

Original language	British English
Pages (from-to)	687-688
Number of pages	2
Journal	Biochemical Journal
Volume	219
Issue number	2
DOIs	https://doi.org/10.1042/bj2190687
State	Published - 1984

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title = "Selective induction of glutathione S-transferase D in rat testis by phenobarbital",

abstract = "Testis cytosol is shown to contain the Yb2Yb2-homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A(Yb1Yb1) and C (Yb1Yb2). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.",

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T1 - Selective induction of glutathione S-transferase D in rat testis by phenobarbital

AU - Sheehan, D.

AU - Ryle, C. M.

AU - Mantle, T. J.

PY - 1984

Y1 - 1984

N2 - Testis cytosol is shown to contain the Yb2Yb2-homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A(Yb1Yb1) and C (Yb1Yb2). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.

AB - Testis cytosol is shown to contain the Yb2Yb2-homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A(Yb1Yb1) and C (Yb1Yb2). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.

UR - https://www.scopus.com/pages/publications/0021246271

U2 - 10.1042/bj2190687

DO - 10.1042/bj2190687

M3 - Article

C2 - 6743236

AN - SCOPUS:0021246271

SN - 0264-6021

VL - 219

SP - 687

EP - 688

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -

Selective induction of glutathione S-transferase D in rat testis by phenobarbital

Abstract

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