Searching for untrodden paths in organocatalysis territory

Guillem Valero, Xavier Companyó, Natalia Bravo, Andrea Nekane R. Alba, Albert Moyano, Ramon Rios

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


In spite of the tremendous growth experienced by the field of asymmetric organocatalysis in the last decade, it is important to realize that we are still far away from having explored all of the possible pathways in organocatalysis territory; the application of the organocatalysis concept can still provide new catalysts and reactions for a variety of asymmetric organic transformations. To exemplify this assertion, we summarize the research performed in our laboratory over the past two years which has led to the development of new enantioselective approaches to organometallic compounds, to the desymmetrization of prochiral ketones, to functionalized cyclopropanes and piperidines, to fluorinated compounds, and to quaternary -amino acids, among others. 1 Introduction 2 Enamine Chemistry 2.1 Ferrocenes: Unprecedented Reactants in Organocatalysis 2.1.1 Organocatalytic Mannich Reactions 2.1.2 Planar Chirality 2.2 Aldol Reaction: Proline-Thiourea Catalysis 2.2.1 Desymmetrization of 4-Substituted Cyclohexanones 2.2.2 Unraveling the Role of the Thiourea Co-catalyst 3 Iminium Chemistry 3.1 Tandem Reactions 3.1.1 Highly Enantioselective Synthesis of Piperidines 3.1.2 Cyclopropanation 3.2 Michael Additions 3.2.1 Anthrones 3.2.2 Fluoromalonates 3.2.3 Sulfones: An Interesting New Tool in Organocatalysis Fluoro-Substituted Sulfones Alkyl Sulfones 3.2.4 Oxindoles 4 Oxazolones: Intriguing Reactants in Organocatalyzed Processes 4.1 Asymmetric Michael Addition of Oxazolones to Nitrostyrenes 4.2 Asymmetric Michael Addition of Oxazolones to Vinyl Sulfones 5 Summary and Outlook.

Original languageBritish English
Pages (from-to)1883-1908
Number of pages26
Issue number13
StatePublished - 2010


  • Amines
  • Asymmetric catalysis
  • Imines
  • Nucleophilic additions
  • Tandem reactions


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