Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: Preparing for an HSV-2 intervention trial

Deborah Watson-Jones, Helen A. Weiss, Mary Rusizoka, Kathy Baisley, Kokugonza Mugeye, John Changalucha, Dean Everett, Rebecca Balira, Louise Knight, David Ross, Richard J. Hayes

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

OBJECTIVES: To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania. METHODS: Two thousand seven hundred nineteen female facility workers aged 16 to 35 were interviewed and underwent serological testing for HIV and HSV-2. Factors associated with HSV-2 and HIV in women aged 16 to 24 were examined using logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: HSV-2 seroprevalence was 80%, and HIV seroprevalence was 30%. Among women aged 16 to 24, both infections were significantly and independently associated with older age, being a bar worker, working at a truck stop, and having more lifetime sexual partners. HSV-2 infection was also associated with lower socioeconomic status, increased alcohol intake, younger age at first sex, inconsistent condom use, and vaginal douching. There was a strong association between the 2 infections after adjustment for other factors (OR = 4.22, 95% CI: 2.6 to 6.9). CONCLUSIONS: Female facility workers in northwestern Tanzania are vulnerable to HSV-2 and HIV infections. Programs designed to increase safer sexual behavior and reduce alcohol use could be effective in reducing HSV-2 incidence and, in turn, HIV infection. This is a suitable population for an HSV suppressive therapy trial.

Original languageBritish English
Pages (from-to)631-642
Number of pages12
JournalJournal of Acquired Immune Deficiency Syndromes
Volume46
Issue number5
DOIs
StatePublished - Dec 2007

Keywords

  • High risk
  • HIV
  • HSV-2
  • Tanzania

Fingerprint

Dive into the research topics of 'Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: Preparing for an HSV-2 intervention trial'. Together they form a unique fingerprint.

Cite this