Reduced QT variability and increased QT/RR slope in ECG signals of depressed patients with suicidal ideation

A. H. Khandoker, V. Luthra, Y. Abouallaban, M. A. Hasan, N. Chowdhury, H. F. Jelinek

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Major depressive disorder (MDD) is associated with a number of comorbidities including cardiovascular disease (CVD), with an increased risk of death after myocardial. The aim of this study was to investigate if parameters for ventricular repolarization variability and dynamics in ECG signals are different in MDD patients with/without suicidal ideation and healthy volunteers. Sixty-one ECG recordings (10 minutes) were acquired and analysed from control subjects (44 CONT), 20 MDD subjects with (MDDSI+) and 21 without suicidal ideation [SI] (MDDSI-) for a case-control analysis at a psychiatric clinic in the UAE. The Mini-International Neuropsychiatric Interview (MINI) made diagnoses of MDD and the subscale for was used to evaluate the patients' suicidal intensions [0 to 38]. The subscale for SI consists of 19 items, which was used to evaluate the patients' suicidal intensions [0 to 38]. Then heart rate-corrected QT interval (QTc), QT/RR slope, QT variability (QTV), Median T-wave amplitudes and T-wave variability were estimated. MDD patients with suicidal ideation displayed increased QT/RR slope and reduced QTV, which may reflect abnormal ventricular repolarization liability and lead to higher risk of cardiac arrhythmia and future cardiovascular diseases.

Original languageBritish English
Title of host publicationComputing in Cardiology Conference, CinC 2016
EditorsAlan Murray
PublisherIEEE Computer Society
Pages393-396
Number of pages4
ISBN (Electronic)9781509008964
DOIs
StatePublished - 1 Mar 2016
Event43rd Computing in Cardiology Conference, CinC 2016 - Vancouver, Canada
Duration: 11 Sep 201614 Sep 2016

Publication series

NameComputing in Cardiology
Volume43
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference43rd Computing in Cardiology Conference, CinC 2016
Country/TerritoryCanada
CityVancouver
Period11/09/1614/09/16

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