Recovery of biotechnological products using aqueous two phase systems

Win Nee Phong, Pau Loke Show, Yin Hui Chow, Tau Chuan Ling

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


Aqueous two-phase system (ATPS) has been suggested as a promising separation tool in the biotechnological industry. This liquid-liquid extraction technique represents an interesting advance in downstream processing due to several advantages such as simplicity, rapid separation, efficiency, economy, flexibility and biocompatibility. Up to date, a range of biotechnological products have been successfully recovered from different sources with high yield using ATPS-based strategy. In view of the important potential contribution of the ATPS in downstream processing, this review article aims to provide latest information about the application of ATPS in the recovery of various biotechnological products in the past 7 years (2010–2017). Apart from that, the challenges as well as the possible future work and outlook of the ATPS-based recovery method have also been presented in this review article.

Original languageBritish English
Pages (from-to)273-281
Number of pages9
JournalJournal of Bioscience and Bioengineering
Issue number3
StatePublished - Sep 2018


  • Aqueous two-phase system
  • Biotechnological products
  • Downstream processing
  • Liquid-liquid extraction technique
  • Recovery


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