TY - GEN
T1 - Recovering the mechanical properties of denatured intervertebral discs through Platelet-Rich Plasma therapy
AU - Khalaf, Kinda
AU - Nikkhoo, Mohammad
AU - Kuo, Ya Wen
AU - Hsu, Yu Chun
AU - Parnianpour, Mohammad
AU - Campbell-Kyureghyan, Naira
AU - Haghpanahi, Mohammad
AU - Wang, Jaw Lin
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/11/4
Y1 - 2015/11/4
N2 - Degenerative disc disease is one of the most common causes of low back pain instigating huge socioeconomic costs and posing an immense burden on healthcare systems worldwide. New therapeutic approaches to damaged intervertebral discs are therefore of great interest. Platelet-Rich Plasma (PRP) has been proposed for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding its effectiveness and influence on disc material properties. The objective of this study was to investigate and quantify the material properties of intact, denatured, and PRP treated discs. A systematic methodology was established in the process, where ex-vivo experiments were conducted and material properties were extracted using an inverse finite element approach. The results showed that PRP is able to recover the mechanical properties of denatured discs, thereby providing a promising effective therapeutic modality.
AB - Degenerative disc disease is one of the most common causes of low back pain instigating huge socioeconomic costs and posing an immense burden on healthcare systems worldwide. New therapeutic approaches to damaged intervertebral discs are therefore of great interest. Platelet-Rich Plasma (PRP) has been proposed for the repair and regeneration of degenerated discs, but there remains a knowledge gap regarding its effectiveness and influence on disc material properties. The objective of this study was to investigate and quantify the material properties of intact, denatured, and PRP treated discs. A systematic methodology was established in the process, where ex-vivo experiments were conducted and material properties were extracted using an inverse finite element approach. The results showed that PRP is able to recover the mechanical properties of denatured discs, thereby providing a promising effective therapeutic modality.
UR - http://www.scopus.com/inward/record.url?scp=84953242530&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2015.7318516
DO - 10.1109/EMBC.2015.7318516
M3 - Conference contribution
C2 - 26736416
AN - SCOPUS:84953242530
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 933
EP - 936
BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Y2 - 25 August 2015 through 29 August 2015
ER -