Recent Advances in Silicon Quantum Dot-Based Fluorescent Biosensors

Yanan Zhang, Ning Cai, Vincent Chan

    Research output: Contribution to journalReview articlepeer-review

    20 Scopus citations

    Abstract

    With the development of nanotechnology, fluorescent silicon nanomaterials have been synthesized and applied in various areas. Among them, silicon quantum dots (SiQDs) are a new class of zero-dimensional nanomaterials with outstanding optical properties, benign biocompatibility, and ultra-small size. In recent years, SiQDs have been gradually utilized for constructing high-performance fluorescent sensors for chemical or biological analytes. Herein, we focus on reviewing recent advances in SiQD-based fluorescent biosensors from a broad perspective and discussing possible future trends. First, the representative progress for synthesizing water-soluble SiQDs in the past decade is systematically summarized. Then, the latest achievement of the design and fabrication of SiQD-based fluorescent biosensors is introduced, with a particular focus on analyte-induced photoluminescence (fluorescence) changes, hybrids of SiQDs with other materials or molecules, and biological ligand-modification methods. Finally, the current challenges and prospects of this field are highlighted.

    Original languageBritish English
    Article number311
    JournalBiosensors
    Volume13
    Issue number3
    DOIs
    StatePublished - Mar 2023

    Keywords

    • bioimaging
    • biosensors
    • fluorescence detection
    • photoluminescent
    • silicon quantum dot

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