Recent advancement challenges with synthesis of biocompatible hemodialysis membranes

Shafiq Uz Zaman, Sikander Rafiq, Abulhassan Ali, Muhammad Shozab Mehdi, Amber Arshad, Saif ur Rehman, Nawshad Muhammad, Muhammad Irfan, Muhammad Shahzad Khurram, Muhammad Khaliq U. Zaman, Abdulkader S. Hanbazazah, Hooi Ren Lim, Pau Loke Show

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The focus of this study is to enhance the protein fouling resistance, hydrophilicity, biocompatibility, hemocompatibility and ability of the membranes and to reduce health complications like chronic pulmonary disease, peripheral vascular disease, cerebrovascular disease, and cardiovascular disease after dialysis, which are the great challenges in HD applications. In the current study, the PSF-based dialysis membranes are studied broadly. Significant consideration has also been provided to membrane characteristics (e.g., flowrate coefficient, solute clearance characteristic) and also on commercially available polysulfone HD membranes. PSF has gained a significant share in the development of HD membranes, and continuous improvements are being made in the process to make high flux PSF-based dialysis membranes with enhanced biocompatibility and improved protein resistance ability as the major issue in the development of membranes for HD application is biocompatibility. There has been a great increase in the demand for novel biocompatible membranes that offer the best performances during HD therapy, for example, low oxidative stress and low change ability of blood pressure.

Original languageBritish English
Article number135626
JournalChemosphere
Volume307
DOIs
StatePublished - Nov 2022

Keywords

  • Biocompatibility
  • Environmental remediation
  • Membranes
  • Polysulfone

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