TY - JOUR
T1 - Rational synthesis of reduced graphene oxide hybrid nanocomposite with iron tungstate for selective detection of epinephrine in biological fluids
AU - Babulal, Sivakumar Musuvadhi
AU - Karuppiah, Chelladurai
AU - Chen, Shen Ming
AU - Babulal, Lakshmipriya Musuvadhi
AU - Palanisamy, Selvakumar
AU - Yang, Chun Chen
AU - Chiesa, Matteo
N1 - Funding Information:
The authors acknowledge the Ministry of Science and Technology, Taiwan (MOST 110-2113-M-027-003) for the financial support of this research. The authors also would like to acknowledge the National Taipei University of Technology, Ming-Chi University of Technology and Khalifa University for providing the necessary support for the study.
Funding Information:
The authors acknowledge the Ministry of Science and Technology, Taiwan (MOST 110-2113-M-027-003) for the financial support of this research. The authors also would like to acknowledge the National Taipei University of Technology, Ming-Chi University of Technology and Khalifa University for providing the necessary support for the study. The manuscript contains all data related to the paper. The corresponding authors will provide any additional data upon request.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/11
Y1 - 2022/11
N2 - Hybrid nanocomposites made from metal tungstate and stacked graphene nanosheets have attracted the curiosity of researchers due to their high conductivity, strong electrochemical activity, and quick electrochemical transfer response. These properties prompted us to employ co-precipitation and sonochemical approaches to create low-cost iron tungstate (FeWO4)/reduced graphene oxide (rGO) hybrid material. The as-synthesized FeWO4/rGO nanocomposites (NCs) were evaluated for their physicochemical properties and structural and morphological aspects. A modified electrode composed of FeWO4/rGO NCs was utilized to detect epinephrine (Eph), a significant neurotransmitter and hormone associated with various human activities. The electrochemical behavior of Eph was quantified using cyclic voltammetry, and differential pulse voltammetry (DPV) on a FeWO4/rGO NCs modified electrode. According to the DPV study, Eph concentration was linearly distributed from 0.05 to 990.5 µM. For determining Eph, the sensor had a detection limit of 0.0073 µM and a sensitivity of 5.857 µAµM−1 cm−2. The sensor displayed excellent recovery results for the determination of Eph in the human urine and epinephrine pills real samples, revealing its excellent practicality.
AB - Hybrid nanocomposites made from metal tungstate and stacked graphene nanosheets have attracted the curiosity of researchers due to their high conductivity, strong electrochemical activity, and quick electrochemical transfer response. These properties prompted us to employ co-precipitation and sonochemical approaches to create low-cost iron tungstate (FeWO4)/reduced graphene oxide (rGO) hybrid material. The as-synthesized FeWO4/rGO nanocomposites (NCs) were evaluated for their physicochemical properties and structural and morphological aspects. A modified electrode composed of FeWO4/rGO NCs was utilized to detect epinephrine (Eph), a significant neurotransmitter and hormone associated with various human activities. The electrochemical behavior of Eph was quantified using cyclic voltammetry, and differential pulse voltammetry (DPV) on a FeWO4/rGO NCs modified electrode. According to the DPV study, Eph concentration was linearly distributed from 0.05 to 990.5 µM. For determining Eph, the sensor had a detection limit of 0.0073 µM and a sensitivity of 5.857 µAµM−1 cm−2. The sensor displayed excellent recovery results for the determination of Eph in the human urine and epinephrine pills real samples, revealing its excellent practicality.
KW - Electrochemical detection
KW - Epinephrine neurotransmitter
KW - Hybrid nanocomposites
KW - Iron tungstate
KW - Practicality
KW - Reduced graphene oxide
UR - http://www.scopus.com/inward/record.url?scp=85141491321&partnerID=8YFLogxK
U2 - 10.1016/j.flatc.2022.100445
DO - 10.1016/j.flatc.2022.100445
M3 - Article
AN - SCOPUS:85141491321
SN - 2452-2627
VL - 36
JO - FlatChem
JF - FlatChem
M1 - 100445
ER -