Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins; Waqas Amin Gill; Rosemarie Kringel; Guankui Wang; Jamie Hass; Suresh Acharya; Jungrae Park; In Tak Jeon; Boo Hyun An; Ji Sung Lee; Jong Eun Ryu; Rod Hill; David McIlroy; Young Keun Kim; Daniel S. Choi

doi:10.1088/1361-6528/28/3/03LT01

Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

Xiaoping Hopkins
, Waqas Amin Gill
, Rosemarie Kringel
, Guankui Wang
, Jamie Hass
, Suresh Acharya
, Jungrae Park
, In Tak Jeon
, Boo Hyun An
, Ji Sung Lee
, Jong Eun Ryu
, Rod Hill
, David McIlroy
, Young Keun Kim
, Daniel S. Choi

Mechanical & Nuclear Engineering

University of Idaho
MinoTech Engineering Inc.
Korea University
Indiana University-Purdue University Indianapolis

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

Original language	British English
Article number	03LT01
Journal	Nanotechnology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1088/1361-6528/28/3/03LT01
State	Published - 20 Jan 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
magnetic core-shell nanowire
RF radiation
RF-mediated thermotherapy

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Hopkins, X., Gill, W. A., Kringel, R., Wang, G., Hass, J., Acharya, S., Park, J., Jeon, I. T., An, B. H., Lee, J. S., Ryu, J. E., Hill, R., McIlroy, D., Kim, Y. K., & Choi, D. S. (2017). Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires. Nanotechnology, 28(3), Article 03LT01. https://doi.org/10.1088/1361-6528/28/3/03LT01

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abstract = "We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.",

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author = "Xiaoping Hopkins and Gill, \{Waqas Amin\} and Rosemarie Kringel and Guankui Wang and Jamie Hass and Suresh Acharya and Jungrae Park and Jeon, \{In Tak\} and An, \{Boo Hyun\} and Lee, \{Ji Sung\} and Ryu, \{Jong Eun\} and Rod Hill and David McIlroy and Kim, \{Young Keun\} and Choi, \{Daniel S.\}",

note = "Funding Information: D S Choi acknowledges support for this work by the Masdar Institute New Faculty Start-up Funds. Y K Kim acknowledges support by the National Research Foundation of Korea (2014M3A7B4052193, 2015R1A2A1A15053002). The authors are thankful to Ms Audrey Harris and Mr Brad Williams in the University of Idaho Laboratory Animal Research Facility for valuable advice on in vivo experiments. Y K Kim is grateful to Ms H W Seo for supplying additional batches of nanowires. D S Choi is also grateful to Dr Barbara Powers at the Diagnostic Laboratory of Colorado State University for help with histological studies. Publisher Copyright: {\textcopyright} 2016 IOP Publishing Ltd.",

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AU - Hass, Jamie

AU - Acharya, Suresh

AU - Park, Jungrae

AU - Jeon, In Tak

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AU - Hill, Rod

AU - McIlroy, David

AU - Kim, Young Keun

AU - Choi, Daniel S.

N1 - Funding Information: D S Choi acknowledges support for this work by the Masdar Institute New Faculty Start-up Funds. Y K Kim acknowledges support by the National Research Foundation of Korea (2014M3A7B4052193, 2015R1A2A1A15053002). The authors are thankful to Ms Audrey Harris and Mr Brad Williams in the University of Idaho Laboratory Animal Research Facility for valuable advice on in vivo experiments. Y K Kim is grateful to Ms H W Seo for supplying additional batches of nanowires. D S Choi is also grateful to Dr Barbara Powers at the Diagnostic Laboratory of Colorado State University for help with histological studies. Publisher Copyright: © 2016 IOP Publishing Ltd.

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N2 - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

AB - We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

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Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

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Keywords

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